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Physostigmine occurs as parasympathomimetic, specifically, a reversible cholinesterase inhibitor obtained from a Calabar bean. By interfering sustaining a metabolism of acetylcholine, physostigmine indirectly stimulates both nicotinic and muscarinic receptors.

Clinical Uses
Physostigmine is utilized to deal with glaucoma. Because it crosses a blood-brain barrier, it is too wont to deal with a central nervous system effects of atropine overdose and other anticholinergic drug overdoses.

Physostigmine is available in the U.S. under a trade list Antilirium, Eserine Salicylate, Isopto Eserine, & Eserine Sulfate.

Sources
Brenner, G. M. (2000). Materia medica. Philadelphia, PA: W.B. Saunders Company. ISBN 0-7216-7757-6 Canadian Apothecary Association (2000). Compendium of Pharmaceutic & Specialties (Twenty-fifth ed.). Toronto, In: Webcom. ISBN 0-919115-76-4

Antilirium Indications and Dose (Physostigmine Salicylate) - RxList Monographs
Use and administration guidelines with links to full prescribing information.

Physostigmine (Ophthalmic) - MedlinePlus
Brief summary for consumers from the National Library of Medicine.